NIH R01 · 2025
Defining the role of Tox3 in congenital cerebellar hypoplasia and ataxia
PROJECT SUMMARY / ABSTRACT The cerebellum is an exquisitely laminated structure regulating balance, voluntary motor coordination and modulating language and cognition through connections with the forebrain. Sitting just under the forebrain, the cerebellum is estimated to contain roughly 80% of the neurons in the human brain. Accordingly, cerebellar dysgenesis, pathology, or dysfunction is associated with a host of diseases or disorders, including ataxia, autism, and intellectual deficit. Most cerebellar neurons are a subtype called cerebellar granule cells (CGCs), which are generated embryonically from a structure termed the rhombic lip (RL)—a germinal zone residing at the interface between…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.