NIH R01 · 2025
Leveraging large-scale genomics to dissect A-to-I editing in brain aging and Alzheimer's disease
PROJECT SUMMARY Post-transcriptional modifications through adenosine-to-inosine (A-to-I) editing are critical for maintaining the diverse repertoire of RNA transcripts in the human brain. These modifications occur at isolated adenosines and across multiple consecutive adenosines within an extended region along the same RNA molecule. A-to-I editing influences gene function, alternative splicing, protein sequences, miRNA binding, and RNA structures. Recent work by us and others show that A-to-I editing is abundant during normal aging and changes in editing levels are tied to etiology of Alzheimer’s disease and related dementias (AD/RD). Nevertheless, substantial gaps persist regarding the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.