NIH R01 · 2024
Rosettes in Adrenal Development, Maintenance and Disease
The adrenal cortex continuously remodels in response to physiological cues, though the precise cellular and molecular mechanisms remain poorly understood. Our prior studies show that the adrenal cortex undergoes zonal transdifferentiation during postnatal development in the zona Glomerulosa (zG) gives rise to the zona Fasciculata (zF). This process involves formation and resolution of multicellular zG-rosettes via the adherens junction(AJ)-aCatenin complex. How these structures regulate aldosterone production and how dysregulation leads to disease is not known. Given that primary aldosteronism (PA), the most common form of endocrine hypertension, involves hyperplasic expansion of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.