NIH R01 · 2025
CD45 mediated regulation of PMN function during intestinal inflammation
Abstract: It has been well documented that disease activity in inflammatory mucosal diseases including inflammatory bowel disease is linked to the transepithelial migration of neutrophils through the mucosal epithelium and ultimately into the intestinal lumen. Co-incident with massive luminal influx of neutrophils is uncontrolled release of toxic tissue damaging metabolites that contribute to mucosal and/or transmural injury including edema, loss of goblet cells, decreased mucus production, crypt cell hyperplasia, ulceration and crypt abscess formation. The complex signaling mechanisms that regulate neutrophil transepithelial migration and inflammatory function in mucosal tissues have not…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.