Bravo-Cordero Lab

Research focus

NIH R01 · 2024

Defining the role of type III collagen and the collagen-binding receptor DDR1 in metastatic dormancy

Project Summary/Abstract Background: Metastasis is the primary cause of death of cancer patients. Disseminated tumor cells (DTCs) leave the primary tumor and seed target organs originating metastasis, years or decades after treatment. This delay in growth is mediated by a process called tumor dormancy. The extracellular matrix (ECM)-tumor cell interactions have been shown to regulate the hallmark of cancer; from primary tumor growth to migration, invasion and metastasis. However, how ECM sensing and remodeling can induce and sustain dormancy of DTCs is unclear. Moreover, whether DTCs assemble dormancy-supportive ECM niches to sustain their phenotype is also an unanswered question. We will…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.