NIH R01 · 2024
Reconstructing the temporal landscape of gene regulation in aging
PROJECT SUMMARY / ABSTRACT The circadian rhythm orchestrates a vast repertoire of biochemical, physiological, and behavioral processes with a 24-hour period. A clock circuit, driven by the oscillatory activation and repression of a set of core clock genes, is present in every cell and regulates the expression of nearly half the genome across all tissues. Abundant epi- demiological evidence links circadian regulation to human health. In particular, sleep and circadian disruption is associated with neurodegeneration, where it is thought to be both a consequence and a risk factor for Alzheimer's disease (AD). As the most common form of dementia in the elderly, AD is rapidly becoming a public…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.