Braun Lab

Brown University

PUBLIC HEALTH & PREV MEDICINE

Providence · United States

NIH-funded
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NIH R01 · 2024

Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health

Exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with adverse cardiometabolic health across the lifespan. Due to their widespread use in consumer and industrial products, the developing fetus, infant, and child may be exposed via transplacental transfer, breast milk, dust ingestion, diet, and drinking water. The long biological half-lives of some PFAS, which can range from 2-7 years in humans, intensifies concerns about the risk of continued exposure and associated health effects. While elevated exposure to PFAS in utero and during childhood may predispose exposed children to increased adiposity, systolic blood pressure, and cholesterol levels, the biological…

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