NIH R01 · 2025
Noncanonical roles of Bim in heat shock-induced cell death
PROJECT SUMMARY/ABSTRACT Severe hyperthermia (heatstroke) is due to a failure of thermoregulation that can lead to cell death in various tissues resulting in multisystem organ failure. Hyperthermia generally results from overexertion due to severe physical activity and/or prolonged exposure to elevated temperatures. Patients who suffer from anhidrosis or hypohidrosis, due to disease or certain medications, such as anesthetics, diuretics, anticholinergics, and amphetamines, are likewise at greater risk. Apart from the negative effects of hyperthermia, in the clinic a variety of approaches are being utilized to induce localized hyperthermia in the treatment of various cancers, as many tumors…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.