NIH R01 · 2024
Modeling the Glioblastoma Microenvironment to Uncover Progression Mechanisms and Therapeutic Targets
In nearly all forms of human cancer, the development of necrosis is tightly linked with malignant progression. Whether necrosis accelerates progression or is largely passive remains an open question, yet modeling these events to establish mechanisms and therapeutic vulnerabilities in animals has been challenging. In glioblastoma (GBM; WHO grade IV), the most malignant primary brain tumor, the rapid, radial growth phase that leads quickly to death is consistently preceded by the development of central necrosis. While genetic alterations of GBM are known in great detail, the biological properties that result from their acquisition and lead to this accelerated growth phase require deeper…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.