NIH R01 · 2024
Mechanisms of voice disorders associated with vocal fold atrophy
ABSTRACT Clinically, atrophy of the intrinsic laryngeal musculature is poorly defined likely related to limited understanding of fundamental biological processes underlying this complex, aberrant tissue phenotype. This lack of insight underlies suboptimal therapeutic strategies for these challenging patients. In addition to fundamental investigation regarding this phenotype, we hypothesize that initiation and maintenance of atrophy of the intrinsic laryngeal musculature is related to signaling events in the mucosa. Specifically, our laboratory elucidated the role of TGF-β signaling with an emphasis on therapeutic strategies targeting the SMAD family of signaling proteins in the vocal fold…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.