NIH R01 · 2025
Mechanisms and Therapeutic Targeting of Chronic Neuroinflammation in Traumatic Brain Injury
Traumatic brain injury (TBI) is one of the leading causes of death and disability in the United States. Research has shown that there is chronic neuroinflammation following TBI, which contributes to progressive neurodegeneration, white matter loss and cognitive decline. Unfortunately, the pathological processes underlying chronic neuroinflammation are poorly understood. The overall objective of the current study is to elucidate the mechanisms that underlie chronic neuroinflammation after TBI and test therapeutic interventions that target these mechanisms. Our central hypothesis is that newly discovered proinflammatory and neurotoxic A1 astrocytes play a key role in chronic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.