Brady Lab

University of Minnesota

FAMILY MEDICINE

Minneapolis · United States

NIH-funded
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NIH R01 · 2024

CARDIA-PLUS: A Life Course Investigation of Biopsychosocial Pathways to Bladder Health and Lower Urinary Tract Symptoms

Project Summary/Abstract This proposal aims to examine four interrelated pathways by which psychosocial and socioeconomic stressors may lead to poorer bladder health (lower urinary tract symptoms [LUTS] and impact of symptoms) among women and men across the life course: affective, cognitive, behavioral, and physiological pathways. The proposed work leverages data and intellectual resources from two NIH initiatives, the 30+ year Coronary Artery Risk Development in Adults (CARDIA) cohort study, initiated in 1985, and the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium, initiated in 2015. LUTS, including overactive bladder (OAB) and urinary incontinence (UI), affect the…

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