NIH R01 · 2025
Understanding the origins of the mutational landscape in cancer
PROJECT SUMMARY Exposure to environmental genotoxins poses a considerable risk, contributing to the formation of pro-mutagenic DNA lesions. These DNA lesions, in turn, can give rise to mutations and ultimately contribute to the development of cancer. Unfortunately, our knowledge of the precise origins of subsequent mutations has been hampered by the inability to comprehensively characterize the DNA lesion landscape, comprised of both the type (DNA adductome) and genomic positions of the DNA lesions. This lack of knowledge about the DNA lesion landscape has resulted in an inability to precisely link DNA lesions to subsequent mutational outcomes. Indeed, many common mutations found in human…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.