NIH R01 · 2024
Mobile element derived chromatin looping variability in human populations
Project Summary Mobile element insertions (MEIs), or transposable elements, have been established to contribute to ongoing mutagenesis of the human genome, leading to widespread variability and sporadic cases of human disease. Recent work has begun to illuminate underlying roles through which MEIs affect regulatory processes through their combined effects on transcription factor binding and 3D chromatin looping. Recent work from our group has demonstrated the importance of MEIs in establishing chromatin looping variability in driving differential gene expression. These observations have precipitated development of molecular and computational approaches to study their impact on human…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.