NIH R01 · 2024
Biomolecules, such as nucleic acids, lipids, and proteins, are nanoscale in size, and often localized with nanoscale precision with respect to each other, and to cellular structures. Analyzing the nanoscale configurations of biomolecules in cells and tissues is critical for understanding how they work, as well as how they go wrong in disease states. Not surprisingly, much effort has been devoted to inventing methods (e.g., super-resolution microscopy, cryo-electron microscopy) for nanoimaging biological specimens, primarily in their preserved state. However, all of these technologies require expensive equipment, and specialized skillsets. Given that all biological systems involve nanoscale…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.