NIH R01 · 2024
Cell signaling through O-GlcNAc reader proteins
Project Summary/Abstract O-linked b-N-acetylglucosamine (O-GlcNAc) is a ubiquitous post-translational modification (PTM) in mammals, decorating thousands of nuclear and cytoplasmic proteins. O-GlcNAc cycling is an essential regulator of myriad aspects of cell physiology and is dysregulated in numerous human diseases, such as cancer, diabetes and neurodegeneration. Despite this broad pathophysiological significance, major aspects of O-GlcNAc signaling remain incompletely understood, including the biochemical mechanisms through which O-GlcNAc transduces information. At the start of our project, several studies had shown that O-GlcNAcylation mediates protein-protein interactions (PPIs) in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.