NIH R01 · 2024
New techniques for detecting and handling nanocrystals for cutting edge structural biology methods
Project Summary Determining the detailed structural characteristics of biomolecules relevant to human health and disease is one of the most crucial tools in our arsenal for understanding disease etiology and mechanism, and for being able to develop new therapeutics that target these molecular entities. There are new techniques in structural biology, including serial femtosecond crystallography, serial synchrotron crystallography, and microcrystal electron diffraction, that have the potential to greatly advance structure determination of biomolecules and to empower access to structural details that have defied characterization via other structural methods. These new structural methods all…
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