NIH R01 · 2024
Mechanisms of Manganese Neurotoxicity
PROJECT SUMMARY Our understanding of how chronic Mn may trigger or promote central nervous system (CNS) morbidities remains fragmentary. Here, we seek to continue our studies into the mechanisms of Mn neurotoxicity by focusing on chronic exposures. Acute Mn cellular neurotoxicity occurs by alterations in cell signaling pathways that normally rely on Mn for their function, e.g., insulin-like growth factor (IGF)/insulin metabolic signaling pathway (IIS), and the highly interconnected mTOR (mTORC1 and mTORC2), AKT and ATM/p53 metabolic signaling systems. Existing research strongly supports a mechanism of Mn neurotoxicity related to the fact that Mn-dependent enzymes are situated at key…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.