Bowles Lab

Research focus

NIH R01 · 2024

Novel Zinc-Finger Protein Regulator of Senescence and Cell Engineering

Cell engineering has provided the opportunity to tune cell function to address therapeutic needs and discover novel biology. We recently performed a set of experimental CRISPR gene perturbation screens that indicated a gene, ZNF865, which is only known through sequence analysis and does not have any in depth publications to date, has significant effects on cell function. Our preliminary data indicate that ZNF865 regulates many genes that modify the cell's overall activity regarding cell cycle, protein processing, senescence, and RNA transport in multiple unrelated cell types. ZNF865 appears to regulate these functions in all human cell types, implying a wide range of potential therapeutic…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.