NIH R01 · 2025
Longitudinal reciprocal relationships between cannabis use, sleep, and the HPA-axis
Summary Cannabis use disorder (CUD) affects at least 10% of the 193 million individuals that use cannabis worldwide. Cannabis is frequently promoted as a sleep aid despite conclusive evidence to support such benefits. Further, abrupt cessation of regular cannabis use is associated with sleep disturbances, often leading to reinitiating cannabis use. Thus, while the mechanisms by which cannabis regulates sleep remains unclear, the escalation and/or maintenance of hazardous levels of cannabis use likely involve a bidirectional (and mutually reinforcing) relationship between sleep and cannabis use. In this prospective mechanistic randomized control study, we will determine the impact of sleep…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.