NIH R01 · 2024
Equipment Supplement to R01GM148610 for an Eppendorf Innova 44R Incubator Shaker
Project Summary The primary goal of R01GM148610: “EmCAST: Stabilizing Proteins and Tuning Dynamics with High Precision and Accuracy” is to further develop and validate the EmCAST algorithm, which uses sequence/structure data available in the Protein Data Bank to predict stabilizing mutations at surface exposed sites of proteins. This goal will be accomplished in three aims. Aims 1 and 2 apply the method to four all- domains, two all- domains and a set of four / domains. Aim 3 applies EmCAST to the problem of tuning the equilibrium between two protein conformers. Reliable methods to stabilize proteins are essential for increasing the shelf life of protein pharmaceuticals and for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.