NIH R01 · 2024
Control of cell wall synthesis and antibiotic tolerance in mycobacteria
There is a critical need to understand the regulation of cell wall metabolism in Mycobacterium tuberculosis because it contributes to antibiotic tolerance, which exacerbates tuberculosis outcomes. The objective of this proposal is to build a molecular model for how environmental information flows through phosphorylation of three cell wall regulators to dynamically control cell wall metabolism in mycobacteria. The central hypothesis of this proposal is that the central regulators of the cell wall during growth also regulate it in stress. This hypothesis is based on our data that the phosphatase PstP controls growth as well as stress responses, and that the phosphorylated regulators CwlM and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.