NIH R01 · 2024
Germline Determinants of Prostate Cancer Evolution
Abstract Prostate cancer is the most commonly diagnosed non-skin cancer in men, and the second most common cause of cancer death for men. It is a high-incidence, high-fatality, high-morbidity and high-cost cancer that is growing increasingly frequent in our aging population. Clinically, the majority of prostate cancers present as indolent, and are unlikely to significantly influence a man’s health over his lifetime. Nevertheless, a significant number of prostate tumors are diagnosed while localized but have substantial metastatic potential. Once these colonize distant sites, they become almost uniformly lethal. Current standard of care for clinical risk-stratification involves serum…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.