NIH R01 · 2025
Rescue of Autoimmune-Associated Long QT Syndrome by Decoy Peptides
PROJECT SUMMARY/ABSTRACT Autoimmunity is increasingly recognized as a novel pathogenic mechanism for cardiac arrhythmias. Several arrhythmogenic autoantibodies have been identified, cross-reacting with different types of surface proteins critically involved in cardiomyocyte electrophysiology, primarily ion channels (autoimmune cardiac channelopathies). Specifically, some of these autoantibodies can prolong the action potential duration, leading to acquired long-QT syndrome (LQTS), a condition known to increase the risk of life-threatening ventricular arrhythmias, particularly Torsades de Pointes (TdP) and sudden cardiac death. The most investigated form of autoimmune LQTS is associated with…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.