NIH R01 · 2025
Molecular Mechanisms of Signal Transduction by Two-Component Regulatory Systems
PROJECT SUMMARY Signal transduction and protein phosphorylation are vital for life. The ability to respond to stimuli is considered a key characteristic of life. Cells detect new conditions, transduce relevant information into a usable form, and execute appropriate responses. Errors in signal transduction can cause reduced fitness or disease. A common strategy is to represent information by the specific and transient placement of phosphoryl groups on proteins. Many pathogens use phosphorylation to regulate virulence in response to host parameters. Thus, understanding the mechanisms, regulation, and impact of phosphoryl group transfer among microbial signaling proteins is of fundamental…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.