NIH R01 · 2025
Influence of hypoxia on the antiviral functions of human intestinal epithelial cells
Project Summary Enteric viruses infect or initiate their lifecycle through the gastro-intestinal tract. Pathogenic enteric viruses (e.g. rotavirus, norovirus) are of major clinical importance as they cause a great fraction of pediatric diarrheal cases globally and can lead to life threatening infection in immune compromised patients. The intestinal epithelial cells constitute the primary barrier that enteric viruses need to face to initiate infection. They are organized in discrete crypt-villus structures with the stem cells located in the crypt region and the most differentiated cells (e.g. enterocytes) at the tip of the villi. Along the crypt/villus structure a steep oxygen gradient…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.