NIH R01 · 2025
The pivotal discovery of RNA viruses, like the bi-segmented, single-stranded arenavirus family, producing defective interfering particles (DIPs) over 50 years ago prompted investigations on their contribution to viral pathogenesis and host immunity. However, many basic questions remain, including the molecular basis for how DIPs are regulated and the contribution of DIPs to virus–host interactions, including the persistence of zoonotic pathogens in their reservoir host. Our overall goal is to identify the cellular machinery responsible for regulating arenavirus DIP production and interrogate the impact DIPs have on reservoir fitness. A major constraint to understanding the true role of DIPs…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.