NIH R01 · 2024
PROJECT SUMMARY In addition to signaling/transcription factor-dependent regulatory mechanisms, lineage-specific gene expression programs in stem cells and their progenies are also regulated epigenetically, i.e., via regulation of covalent DNA/histone modifications and higher-order chromatin remodeling. Epigenetic regulatory machinery maintain the progenitor population and epithelial identity in epidermal keratinocytes, as well as inhibit premature activation of terminal differentiation-associated genes and balance their transcription in differentiating cells. Transposable elements (TEs) constitute a large portion (44%-55%) of the entire mouse or human genomes. Most TEs are transcriptionally…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.