Bose Lab

University of Kansas Medical Center

MICROBIOLOGY/IMMUN/VIROLOGY

Kansas City · United States

NIH-funded
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NIH R01 · 2025

Exogenous fatty acid utilization by Staphylococcus aureus

PROJECT SUMMARY Fatty acids are an indispensable part of life since they are an essential component of membranes. In addition, they can serve a variety of other purposes, from an energy source to part of signaling molecules. Most bacteria can generate their own fatty acids through a biosynthesis pathway. However, bacteria can also scavenge fatty acids from the environment, including other bacteria and plant or mammal sources. This includes both free fatty acids and as components of larger molecules. These external fatty acids can be used by bacteria to supplement the fatty acid biosynthetic pathway or as an energy source. In Gram-positive bacteria, external fatty acids can be incorporated…

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