NIH R01 · 2025
Automated interactive definition of the clinical target volume in radiation oncology
Abstract Identifying the appropriate clinical target volume (CTV) to capture microscopic disease is the greatest limitation in clinical radiotherapy in efforts to offer maximally conformal treatment to minimize radiation associated toxicity. The challenge of defining the CTV comes from inherent uncertainty in the tumor spread beyond the visible gross tumor volume (GTV). Delineation of the CTV is a laborious manual process. Furthermore, there exists a practical disconnect between CTV contouring and the subsequent treatment plan dose optimization. Exploration of the real tradeoff between covering malignancy with the dose effective for tumor control and delivering potentially toxic dose to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.