NIH R01 · 2024
PROJECT SUMMARY: Overview: The molecular mechanisms by which corneal nerves regulate limbal stem cells (LSCs), required for corneal epithelial maintenance and wound healing, and ultimately critical for vision, are unknown. When corneal nerves are impaired or absent, patients develop nonhealing corneal wounds that lead to permanent blindness, a condition known as neurotrophic keratopathy (NK). Our objective is to determine the mechanisms by which corneal nerves govern epithelial renewal. In this research proposal we plan to define key cellular and molecular regulators of LSCs that will broaden our knowledge of stem cell biology and will enable development of topical therapeutics for patients…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.