NIH R01 · 2024
Harnessing scandium chelation chemistry for the development of radiopharmaceuticals
The recent FDA-approval of 68Ga-imaging radiopharmaceuticals and their 177Lu-based companion therapeutics underscores the potential of metallic radioisotopes for clinical applications in diagnostic and therapeutic nuclear medicine. The improvements made to accelerator-based production of radiometals beyond the 68Ga, 177Lu theranostic pair has opened opportunities to produce radiometals with a broad range of half-lifes and emission properties, expanding the scope of imageable disease targets. However, subsequent development of clinically applicable radiopharmaceuticals has been impeded by a significant gap in knowledge of aqueous coordination chemistry of the corresponding metal ions.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.