NIH R01 · 2025
Mechanisms of folate action during nervous system development
Abstract Supplementation with the vitamin B9, folate, during pregnancy reduces the incidence of neural tube defects (NTDs), one of the most common and serious birth defects diagnosed in human fetuses and newborns. NTDs result from the failure of neural tube closure during early fetal development, which potentially exposes the neural tissue to a toxic environment and mechanical trauma, resulting in neural tissue degeneration and severe neurological consequences, including fetus and newborn death. Under the previous funding period we made a paradigm-shifting discovery, that the rescue by folate of folate receptor 1 (FOLR1) deficiency-induced NTD phenotype in Xenopus laevis embryos and in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.