NIH R01 · 2024
Central mechanisms of glucocorticoid circadian rhythm dysfunction in breast cancer
Project Summary Breast cancer is still the most common malignancy in women worldwide. Despite the incredible advances made in the past decades towards eliminating breast cancer, nearly all women with metastatic breast cancer will succumb to the disease. Therefore, we desperately need new and improved approaches towards eliminating breast cancer. The proposed work focuses on a widely documented clinical finding with no known underlying mechanism: blunted circulating glucocorticoid rhythms in patients with breast cancer. Critically, patients with ‘flat’ or ‘blunted’ circadian rhythms in circulating glucocorticoids (e.g., cortisol) report lower quality of life and die from cancer earlier than…
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