NIH R01 · 2025
Nucleophosmin Centered Diagnostics and Treatment of Ischemic Acute Kidney Injury
Project Summary/Abstract We discovered that NPM1, a required Bax chaperone, promotes regulated cell death and acute kidney injury (AKI) in the ischemic human kidney. The structure-function relationships (SAR) of NPM1 and its site of interaction with Bax are unknown, limiting the development of novel drugs to prevent NPM/Bax toxicity in kidney cells that are vulnerable to ischemic injury. Our integrative, cross disciplinary strategy combines cell biology with structural and medicinal chemistry to identify the features that render NPM toxic to kidney cells and localize the NPM domain responsible for binding Bax. Using protein structural analysis with x-ray crystallography, photo-labeling and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.