NIH R01 · 2025
Epigenetic modification of HIV-1 Cap
Project summary Basic research opens the door to better understand, treat, and ultimately prevent existing and emerging public health threats. NIAID has prioritized fundamental research into underpinnings of the HIV-associated chronic immune activation despite the control of viral load by daily antiretroviral medication. Recent findings of the HIV-1 RNA cap hyper methylation reveal a new paradigm of viral RNA regulation that finely tunes viral gene expression for adaptive and sustained virus replication in host immune cells. Revealing preliminary research on a new generation of HIV drug, which compromises replication of HIV clinical isolates without positive selection for drug resistance,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.