Borengasser Lab

University of Oklahoma Hlth Sciences Ctr

PEDIATRICS

Oklahoma City · United States

NIH-funded
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NIH R01 · 2024

Preconception Maternal Nutrition, Offspring DNA Methylation, and InfantGrowth in Low Resource Settings

PROJECT ABSTRACT Growth stunting is a global health problem that impacts ~149 million children under 5 years of age living primarily in low-and-middle income-countries, particularly low-income countries. Mothers and infants are particularly vulnerable to the impacts of malnutrition, including inadequacy of micronutrients which contributes to stunted growth resulting in life-long morbidity and mortality, lower education achievement, and loss of human capital. The goal of this proposal is to determine if a preconception maternal nutrition supplement can alter targeted and epigenome-wide DNA methylation (DNAme) in infants born in regions prone to high rates of growth stunting. DNAme is an…

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