NIH R01 · 2024
PROJECT SUMMARY This R01 proposal tests the central hypothesis that gonadal hormones present during a critical window of perinatal brain organization result in distinct sex-specific microglial and mitochondrial phenotypes that increase male vulnerability to perinatal immune stimuli. There is a strong male bias in the incidence of many early-onset neurodevelopmental disorders. Although neurodevelopmental disorders are quite heterogeneous, growing evidence demonstrates immune and mitochondrial abnormalities in a subset of these patients. Microglia, the innate immune cells of the brain, have emerged as key effectors of this neuroimmune communication. We find that microglia isolated from mice…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.