NIH R01 · 2025
Automated chemo-enzymatic synthesis of N-glycans for host-pathogen interactions
SUMMARY Numerous viruses initiate infection by binding to cell surface glycans of the host. The selectivities of viral receptor binding proteins for specific glycans critically determine host range, tissue- and cell tropism and pathogenesis. A detailed understanding of receptor usage by respiratory viruses is critical for the development of surveillance, prevention and intervention strategies to mitigate risks of future pandemic outbreaks. Glycan receptor usage by respiratory viruses have been difficult to probe because of a lack of appropriate panels of glycans for structure-activity studies. The latter is due to limitations in synthetic methodologies that do not permit the preparation of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.