NIH R01 · 2024
The role of NosP in Pseudomonas aeruginosa biofilm development
Bacterial biofilms are a public health threat because they cause chronic and hospital-acquired infections but are resistant to antibiotics. Failure to characterize the biochemical machinery that drives biofilm dispersal risks missing key targets for treatment of infectious disease. Although nitric oxide (NO)-triggered biofilm dispersal in Pseudomonas aeruginosa (PA), a principal pathogen in cystic fibrosis and hospital-acquired infections, is well documented, the underlying biochemical processes responsible are not understood. To bridge this knowledge gap, a long-term goal of the PI is to determine the mechanism of NO signaling in bacteria and to use this knowledge to develop therapeutic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.