Bonney Lab

Research focus

NIH R01 · 2025

Does the maternal environment during viral infection and inflammation direct fetal T cell development and function?

Project Summary Increasing evidence suggests that maternal inflammation/infection-induced immune activation (MIA) during pregnancy can lead to sustained, long-lasting changes in immune function of the offspring, which could alter disease susceptibility later in life. During pregnancy, the developing fetus is continuously exposed to a variety of factors at the maternal-fetal interface that can have a significant influence on fetal immune development. The fetal immune system is characterized by the development of innate and innate-like immune cells possessing highly specialized functions distinct from their adult-derived counterparts. One example, and the focus of this proposal, are the…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.