NIH R01 · 2024
SUMMARY Transcription stability enforces cellular identity and is tightly controlled by restrictions imposed on both transcription factor function and target gene accessibility. Progression of cancer to metastasis and multi-drug resistance requires fluid transcriptional programs that can explore different genomic landscapes to enable clonal diversification and the origination of aggressive and treatment resistant phenotypes. In this application, we explore the recent discovery that an increase in the production of mitochondrial reactive oxygen species (mtROS), induced by heavy metal contaminants (such as arsenic, lead and cadmium) promotes histone H3.1 oxidation, eviction from nucleosomes…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.