NIH R01 · 2024
The Origins of Human Anti-Insulin B Lymphocytes in Type 1 Diabetes
PROJECT SUMMARY B lymphocytes orchestrate autoimmune beta cell attack in type 1 diabetes (T1D) by presenting autoantigen to T cells which kill beta cells. Circulating insulin autoantibodies (IAAs) are not directly pathogenic but help predict T1D by signaling this dangerous B/T lymphocyte crosstalk. Immune targeting of insulin-producing beta cells occurs for months or even decades before symptomatic diabetes onset. Heterogeneity in diabetes progression and clinical trial responses slow the search for a T1D cure. Better biomarkers to identify and mechanistically explain responders are needed to overcome this bottleneck. Protective immune responses typically arise by T cell selection and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.