NIH R01 · 2024
Regulation of viral-bacterial co-infections by immunometabolism
SUMMARY/ABSTRACT Pseudomonas aeruginosa is a major respiratory pathogen in the pathogenesis of Cystic Fibrosis (CF) and the ineffective immune response to this pathogen is thought to cause the majority of the lung damage characteristic of this disease. In the later stages of CF, P. aeruginosa reside in biofilm communities in the lung, accounting for their resistance to antibiotic therapies. To date, little is known about host factors that promote the transition of P. aeruginosa from acute to chronic infection in CF. CF patients show a reduced ability to clear P. aeruginosa acquired during respiratory viral infections and frequently new pseudomonal colonization in people with CF follows a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.