NIH R01 · 2024
Synaptic and neuronal mechanisms of fear control: the role of hippocampal-amygdalar interactions
Projections from the ventral hippocampus (vHPC) to the amygdala, its basolateral nucleus (BLA), specifically, play an essential role in context representation in the amygdala during encoding of fear memory extinction. However, synaptic and network-level mechanisms by which vHPC-amygdala projections may control the function of the amygdala and amygdala-dependent fear-related behaviors are largely unknown. Combining the use of chemogenetic and optogenetic techniques with ex vivo and in vivo electrophysiology, tract tracing with viral vectors and behavioral training and testing, we will explore the functional roles of vHPC-amygdala projections in conditioned fear and fear extinction at…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.