NIH R01 · 2024
Non-invasive Monitoring for Infections and Rejection after Lung Transplantation
Project Summary Over 4,000 patients receive life-saving lung transplants every year. Unfortunately, chronic respiratory infection frequently complicates these cases and undermines the long-term benefits of this procedure. However, it can be difficult to identify infections early or to distinguish them from rejection. Unfortunately, the current diagnostic gold standard, bronchoalveolar lavage (BAL) fluid culture, is invasive and impractical. We need better, non-invasive ways to diagnose lung infections. One novel but currently insufficient technology that could be developed for this purpose is Next Generation Sequencing of circulating free DNA (cfDNA). These degraded DNA fragments are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.