NIH R01 · 2024
Mechanistic basis of how LD-transpeptidases protect against outer membranedefects
Project Summary/Abstract The emergence of multidrug and extensively drug-resistant Gram-negative bacteria is a growing problem that threatens established antimicrobial treatment protocols. Acinetobacter baumannii is a critical threat pathogen notorious for its ability to rapidly develop multidrug resistance. A. baumannii causes hospital-acquired infections, which manifest as bacteremia, urinary tract and wound infections. In the US, an estimated 60% of hospital-acquired A. baumannii infections were multidrug-resistant, often including carbapenem resistance, which leaves colistin as the “last-resort” treatment option. However, colistin resistance has also emerged. There is an urgent need to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.