NIH R01 · 2024
Project Summary / Abstract Persistence of HIV-1 in tissue reservoirs of therapy-suppressed, aviremic individuals is a major challenge to HIV-1 cure. The viral reservoir consists of myeloid and lymphoid cells that harbor the virus through long periods of combination anti-retroviral therapy (cART). Until recently, it was thought that HIV-1 provirus remains in a transcriptionally-silent, latent state in these reservoir cells and only resumes viral transcription and virion production upon activation from endogenous or exogenous stimuli. However, it is now evident that in a subset of reservoir cells, the virus remains transcriptionally-active even under cART and continues to generate some levels…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.