NIH R01 · 2025
Mechanisms of CD4 T cell help to myeloid cells in tuberculosis
ABSTRACT CD4 T cells govern host control of M. tuberculosis (Mtb) infection. The diverse phagocytic myeloid cells that harbor intracellular Mtb in the lungs require CD4 T cell help to activate antibacterial effector mechanisms. Protection against tuberculosis (TB) depends on this cellular interaction, but it remains incompletely defined. In our preliminary studies, we discovered that myeloid cells in the lungs of Mtb infected mice critically depend on T cells to deploy a broad program of transcriptional activity that controls intracellular infection. These pathways, constituting the spectrum of T cell help, included some pathways known to be due to adaptive immune function, but also others…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.