NIH R01 · 2024
Role of Protein Tyrosine Phosphatase 1B in Cardiac Hypertrophy
Project Summary Oxidative stress is associated with reduced left ventricular (LV) function and correlates with the severity of heart failure in patients. We have recently demonstrated that Protein Tyrosine Phosphatase 1B (PTP1B) becomes reversibly oxidized and inactivated in pressure overload-induced cardiac hypertrophy and that PTP1B inactivation causes profound changes in thyroid hormone responsiveness. We showed that inhibiting the synthesis of triiodothyronine (T3) rescued the exacerbated pressure overload-induced hypertrophy and improved myocardial contractility and systolic function in cardiomyocyte-specific PTP1B knockout mice (PTP1B cKO). We hypothesize that as hypertrophy develops,…
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